Hoffman developed the process for the Bayer Company. In this experiment, acetic anhydride was used as it is cheap, and forms a non-corrosive by-product, acetic acid which can be reused to make more acetic anhydride. To purify the crude product by Recrystallization. This requires that you research the exact error message that's listed on the Blue Screen. Mizukami Abstract Acetylsalicylic acid, or also known as aspirin is known to be a drug that relives people of pain and is commonly used even today. As a result, if we were to improve this experiment, we would use an indicator such as bromthymol in all titrations that has a specific color for a neutral solution to increase the accuracy of the titrations.
The flask was rinsed with distilled water and dried as much as possible. Due to apparent wetness of the product it is estimated that half of the mass is due to moisture. Step 6 The flask was removed from the water bath and 2 mL of ice-cold distilled water was added in a dropwise manner. Next, the crystals and filter paper was transferred onto the weighed watch glass and then dried in the oven 100? One of the more obvious things seen is the inefficiency of small-scale synthesis reactions. After that, one by one, an aspirin tablet was dropped into an Erlenmeyer flask filled with 50 mL of D-water so that it could become dissolved. Aspirin, Impurity, Liquid 1290 Words 5 Pages Aspirin or acetylsalicylate acid is a compound that is widely used in medicine.
Now place the crude product from the weigh boat in a 25 mL Erlenmeyer flask and add 3 mL of ethyl acetate. Save the file to your Desktop so that we can access the file easily. Introduction Aspirin acetylsalicylic acid is a versatile drug that is consumed in huge quantities worldwide. This was the outcome required and was achieved based on this test. If the experiment went as expected, a pure sample of aspirin with a high percent yield would have been obtained.
According to Escobel, 2011 , Aspirin is synthesized through the reaction of salicylic acid with acetyl anhydride that causes a chemical reaction that turns salicylic acid's hydroxyl group. The salicylic acid and the acetic anhydride were mixed in a flask. After cooling for an additional 5 minutes, pour the contents in the 125mL Erlenmeyer flask into a Buchner funnel attached to the vacuum filtration apparatus. Acetic acid, Acetic anhydride, Aspirin 391 Words 2 Pages Synthesis of Acetaminophen Lab Report Bijal Patel, 20467049 Partner: Poojan Parikh T. Aspirin is the most widely used over-the-counter drug in the world. Other tests that were performed were summarized in Table 7. Sulfuric acid being a strong oxidizer reacts more readily with molecules involved in the reaction than with acetic acid, leading to a low percent yield.
A large melting point range would suggest an impure sample and ineffective recrystallization process. The polar oxygen accepts the electrons from now positively charged hydrogen. It is prepared by the esterification of the phenolic hydroxyl group of salicylic acid using acetic anhydride. Cool the Erlenmeyer flask containing the mixture in the ice bath set up previously for 20 minutes. After the solution had come to room temperature, it was carefully submerged in an ice bath to complete the crystallization process. Exothermic side reactions would increase the reaction temperature more quickly even if the salicylic acid acetylation rate had not changed. Place the Erlenmeyer flask in an ice bath for 30 minutes.
A small amount of the Acetylsalicylic Acid was packed into the capillary tube and placed into the apparatus. Preparing esters from an alcohol and a carboxylic acid using an acid as catalyst is one of the most useful reactions in an organic chemists toolbox. The third factor that caused a low percent yield of our purified product was that when we vacuum filtered our purified product, some of our purified product fell through the filter and into the side arm flask. Acetic acid, Acetic anhydride, Aspirin 1897 Words 8 Pages Introduction: The purpose of this lab was to learn how to use salicylic acid to make aspirin. However, it was strongly acidic making it hard to swallow and caused irritation to the lining of the mouth and stomach.
In part 1, the beaker in which the product was heated had to be kept close to 70 degrees Celsius or else different reactions would start taking place. The process of synthesizing aspirin is an esterification reaction, meaning that the phenol group of the salicylic acid reacts with an acid anhydride, the functional group of acetic anhydride, to make ester. The initial temperature was recorded using an alcohol thermometer. The solid aspirin product was trapped by the filter and the liquid was drawn through the funnel into the flask below it by a vacuum. The product was collected in the Buchner funnel via vacuum filtration.
After this vacuuming, spread out the Aspirin evenly on a labeled watch glass and put it in the oven for 30 minutes. After doing this, heat the beaker gently until it begins to boil, at which point remove it and allow it to sit for three minutes. The reaction solution was stirred with a thermometer for a few seconds to ensure that all reagents and the cataylst had appropriate molecular interface. It is important to note, however, that the standard deviation of the sodium acetate — catalyzed reaction 31. The first discovery of aspirin occurred in England, in 1963, believing that the bark of willow trees with a beneficial effect in alleviating distress due to fevers, aches, and pains2. Aim To determine the percentage of aspirin in different commercial preparations and to find which is the best value for money 2. The time values for each reaction were averaged with the other class values and standard deviation was calculated.
Background The active ingredient in aspirin, acetylsalicylic acid, is a synthetic derivative of a compound, salicin found commonly in willow trees. With these elements in mind, it will be possible for you and your writer to collaborate towards producing a high-quality lab report. Using the ring stand and a 3-finger clamp, the 125mL Erlenmeyer flask, containing the contents of all four test tubes, was lowered into the ice water bath. Aspiring functions by inhibiting the synthesis of thromboxanes and prostaglandins in the human body. Small esters are actually fairly soluble in water but solubility falls with chain length and hydrophobic parts. Medication errors are common in the hospital setting and especially by a nurse who is fatigued from working a 12-hour shift. This factor could have distorted all results consequently when comparing, all would have the same distortion.